Blar i forfatter "Singh, Amrinder"

Viser treff 1-2 av 2

    • Falsifiable Network Models. A Network-based Approach to Predict Treatment Efficacy in Ulcerative Colitis 

      Singh, Amrinder (Doctoral thesis; Doktorgradsavhandling, 2022-12-09)
      This work is focused on understanding the treatment efficacy of patients with ulcerative colitis (UC) using a network-based approach. UC is one of two forms of inflammatory bowel disease (IBD) along with Crohn’s disease. UC is a debilitating condition characterized by chronic inflammation and ulceration of the colon and rectum. UC symptoms occur gradually rather than abruptly, and the degree of ...

    • Identifying anti-TNF response biomarkers in ulcerative colitis using a diffusion-based signalling model 

      Singh, Amrinder; Anderssen, Endre; Fenton, Christopher Graham; Paulssen, Ruth H (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-18)
      <p><i>Motivation:</i> Resistance to anti-TNF therapy in subgroups of ulcerative colitis (UC) patients is a major challenge and incurs significant treatment costs. Identification of patients at risk of nonresponse to anti-TNF is of major clinical importance. To date, no quantitative computational framework exists to develop a complex biomarker for the prognosis of UC treatment. Modelling patient-wise ...